Targeted CT/MR dual mode imaging of human hepatocellular carcinoma using lactobionic acid-modified polyethyleneimine-entrapped gold nanoparticles

Du Li; Jia Yang; Shihui Wen; Mingwu Shen; Linfeng Zheng; Guixiang Zhang; Xiangyang Shi

doi:10.1039/C7TB00286F

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Targeted CT/MR dual mode imaging of human hepatocellular carcinoma using lactobionic acid-modified polyethyleneimine-entrapped gold nanoparticles†

Du Li,‡^a Jia Yang,‡^b Shihui Wen,^c Mingwu Shen,*^c Linfeng Zheng,^b Guixiang Zhang*^b and Xiangyang Shi

*^acd

Author affiliations

* Corresponding authors

^a State Key Laboratory for Modification of Chemical Fibers and Polymer Materials & College of Materials Science and Engineering, Donghua University, Shanghai 201620, People's Republic of China
E-mail: xshi@dhu.edu.cn

^b Department of Radiology, Shanghai General Hospital, School of Medicine, Shanghai Jiaotong University, 100 Haining Road, Shanghai 200080, People's Republic of China
E-mail: guixiangzhang@sina.com

^c College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, People's Republic of China

^d CQM-Centro de Química da Madeira, Universidade da Madeira, Campus da Penteada, 9000-390 Funchal, Portugal

Abstract

We report the synthesis and characterization of lactobionic acid-modified multifunctional polyethyleneimine-entrapped gold nanoparticles for targeted dual mode computed tomography/magnetic resonance imaging. The nanodevice displays good X-ray attenuation properties, good r₁ relaxivity, and hepatocellular carcinoma targeting specificity, and can be used for targeted CT/MR imaging of hepatocellular carcinoma in vitro and in vivo.

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Article information

DOI: https://doi.org/10.1039/C7TB00286F
Article type: Communication
Submitted: 26 Jan 2017
Accepted: 06 Mar 2017
First published: 08 Mar 2017

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J. Mater. Chem. B, 2017,5, 2395-2401

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Targeted CT/MR dual mode imaging of human hepatocellular carcinoma using lactobionic acid-modified polyethyleneimine-entrapped gold nanoparticles

D. Li, J. Yang, S. Wen, M. Shen, L. Zheng, G. Zhang and X. Shi, J. Mater. Chem. B, 2017, 5, 2395 DOI: 10.1039/C7TB00286F

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Journal of Materials Chemistry B

Targeted CT/MR dual mode imaging of human hepatocellular carcinoma using lactobionic acid-modified polyethyleneimine-entrapped gold nanoparticles†

Abstract

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Article information

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Targeted CT/MR dual mode imaging of human hepatocellular carcinoma using lactobionic acid-modified polyethyleneimine-entrapped gold nanoparticles

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