Issue 14, 2017

Anti-cancer activity of camptothecin nanocrystals decorated by silver nanoparticles

Abstract

The emergence of multidrug resistant cancer phenotypes dramatically attenuates the efficiency of a variety of anti-cancer drugs. Silver nanoparticles (AgNPs) display excellent anti-cancer activity and dramatic inhibitory effect on drug resistance related proteins like P-glycoprotein (Pgp). Here we developed a novel drug nanocrystal formulation of Camptothecin (CPT), a broad spectrum anti-cancer agent, decorated by AgNPs. The resulting combinational formulation of CPT and AgNPs, named as CPT/Ag nanocrystals, demonstrated excellent dispersion properties and an improved dissolution rate, drug stability and cellular uptake rate. Because CPT nanocrystals are able to bypass Pgp recognition and AgNPs inhibit both Pgp expression and activity, CPT/Ag nanocrystals showed extreme and indiscriminate cytotoxicity against a variety of both drug sensitive and drug resistant cancer cells. Moreover, the quickly and plenty of released CPT from the CPT/Ag nanocrystals triggered by the tumor microenvironment led to a relaxed and cleavable chromatin structure, facilitating DNA damage and apoptotic potential of AgNPs that were subsequently released.

Graphical abstract: Anti-cancer activity of camptothecin nanocrystals decorated by silver nanoparticles

Supplementary files

Article information

Article type
Paper
Submitted
11 Jan 2017
Accepted
11 Mar 2017
First published
13 Mar 2017

J. Mater. Chem. B, 2017,5, 2692-2701

Anti-cancer activity of camptothecin nanocrystals decorated by silver nanoparticles

H. Zhan, X. Zhou, Y. Cao, T. Jagtiani, T. Chang and J. F. Liang, J. Mater. Chem. B, 2017, 5, 2692 DOI: 10.1039/C7TB00134G

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements