Issue 12, 2017

Engineering chemical reaction modules via programming the assembly of DNA hairpins

Abstract

The architect of enzyme-free chemical reaction modules, working as building blocks in implementing complex computing tasks, was achieved by modulating the assembly of DNA hairpins, including non-catalytic and catalytic systems. The performance of heterogeneous outputted sequences, which were programmed on different hairpins for triggering the downstream reaction, was asymmetric in the non-catalytic system, whereas symmetric in the catalytic system. Furthermore, complicated DNA-only chemical modules possessing controllable species of inputs or outputs were constructed based on our strategy. The kinetic studies revealed that the performance of the chemical modules was toehold length correlated; on the basis of which, a DNA concentration monitor was constructed.

Graphical abstract: Engineering chemical reaction modules via programming the assembly of DNA hairpins

Supplementary files

Article information

Article type
Paper
Submitted
29 Nov 2016
Accepted
25 Feb 2017
First published
27 Feb 2017

J. Mater. Chem. B, 2017,5, 2297-2301

Engineering chemical reaction modules via programming the assembly of DNA hairpins

T. Song, X. Wang and H. Liang, J. Mater. Chem. B, 2017, 5, 2297 DOI: 10.1039/C6TB03098J

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