Issue 43, 2016

Hollow mesoporous carbon nanocarriers for vancomycin delivery: understanding the structure–release relationship for prolonged antibacterial performance

Abstract

Mono-dispersed mesoporous hollow carbon (MHC) nanospheres with comparable structures have been designed as nanocarriers for the delivery of vancomycin (Van) to inhibit bacterial growth. It is demonstrated that MHC materials possess a Van loading capacity of 861 mg g−1, much higher than that of any Van nanocarrier in previous reports. By comparing the drug loading, release and antibacterial performance of MHC nanospheres with controllable structures, it is shown that MHC with a pore size of 5.8 nm and a wall thickness of 25 nm exhibits compromising storage–release behaviour and achieves extended bactericidal activity of Van towards E. coli and S. epidermidis compared to free Van and other MHC nanocarriers. This study provides new knowledge about the rational design of carbon based nanocarriers to enhance the therapeutic efficacy of antibiotics.

Graphical abstract: Hollow mesoporous carbon nanocarriers for vancomycin delivery: understanding the structure–release relationship for prolonged antibacterial performance

Supplementary files

Article information

Article type
Paper
Submitted
15 Jul 2016
Accepted
03 Oct 2016
First published
04 Oct 2016

J. Mater. Chem. B, 2016,4, 7014-7021

Hollow mesoporous carbon nanocarriers for vancomycin delivery: understanding the structure–release relationship for prolonged antibacterial performance

Y. Ahmad Nor, H. Zhang, S. Purwajanti, H. Song, A. K. Meka, Y. Wang, N. Mitter, D. Mahony and C. Yu, J. Mater. Chem. B, 2016, 4, 7014 DOI: 10.1039/C6TB01778A

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