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Issue 39, 2015
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Sterically stabilized spongosomes for multidrug delivery of anticancer nanomedicines

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Abstract

Multidrug delivery devices are designed to take advantage of the synergistic effects of anticancer agents in combination therapies. Here we report novel liquid crystalline self-assembled nanocarriers enhancing the activity of the phytochemical anticancer agent baicalin (BAI) in combination with Brucea javanica oil (BJO), which ensures safe formulations for clinical applications. Small-angle X-ray scattering (SAXS) and cryogenic transmission electron microscopy (cryo-TEM) evidenced the multicompartment, sponge-type nano-organization of the blank and multidrug-loaded liquid crystalline carriers. Physico-chemical stability of the sponge nanoparticles was achieved through PEGylation of the lipid membranes, which make up the drug nanocarriers. The proposed green nanotechnology for nanocarrier preparation by supramolecular self-assembly provided a multidrug encapsulation efficiency as high as 75%. The apoptosis study with the human lung carcinoma cell line A549 demonstrated improved efficacy of the multidrug delivery nanocarriers in comparison to the single-drug reservoirs. The obtained results evidenced the synergistic anticancer apoptotic effects of the multidrug-loaded nanosponge carriers and suggested the opportunity for in vivo translation towards the treatment of lung, gastrointestinal, and ovarian cancers.

Graphical abstract: Sterically stabilized spongosomes for multidrug delivery of anticancer nanomedicines

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Publication details

The article was received on 23 Jun 2015, accepted on 10 Aug 2015 and first published on 10 Aug 2015


Article type: Paper
DOI: 10.1039/C5TB01193K
Citation: J. Mater. Chem. B, 2015,3, 7734-7744
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    Sterically stabilized spongosomes for multidrug delivery of anticancer nanomedicines

    Y. Chen, A. Angelova, B. Angelov, M. Drechsler, V. M. Garamus, R. Willumeit-Römer and A. Zou, J. Mater. Chem. B, 2015, 3, 7734
    DOI: 10.1039/C5TB01193K

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