Jump to main content
Jump to site search

Issue 42, 2015
Previous Article Next Article

Folic acid-tethered poly(N-isopropylacrylamide)–phospholipid hybrid nanocarriers for targeted drug delivery

Author affiliations

Abstract

A series of temperature-responsive lipopolymers have been synthesized by bioconjugating poly(N-isopropylacrylamide)n (n = 25, 40, 60) onto three different phospholipids by the combination of reversible addition fragmentation chain transfer polymerization and azide–alkyne click reactions. To achieve the active targeting of cancer cells, folic acid (FA) has also been tethered to the resulting hybrid materials. The doxorubicin (Dox) encapsulated uniform nanocarriers (150 nm in diameter) fabricated by the self-assembly of the lipopolymers display temperature responsive controlled release. The FA receptor-mediated delivery of Dox was then assessed using KB cell lines, and the anti-cancer activity was assessed by the blocking of folic acid receptors. The FA-tethered lipopolymers showing temperature-responsiveness are advantageous for the cell-specific release of Dox, potentiating their anti-cancer activity.

Graphical abstract: Folic acid-tethered poly(N-isopropylacrylamide)–phospholipid hybrid nanocarriers for targeted drug delivery

Back to tab navigation

Supplementary files

Publication details

The article was received on 03 Jun 2015, accepted on 30 Aug 2015 and first published on 01 Sep 2015


Article type: Paper
DOI: 10.1039/C5TB01063B
Author version
available:
Download author version (PDF)
Citation: J. Mater. Chem. B, 2015,3, 8268-8278
  •   Request permissions

    Folic acid-tethered poly(N-isopropylacrylamide)–phospholipid hybrid nanocarriers for targeted drug delivery

    J. V. John, Y. Jeong, R. P. Johnson, C. Chung, H. Park, D. H. Kang, J. K. Cho, Y. Kim and I. Kim, J. Mater. Chem. B, 2015, 3, 8268
    DOI: 10.1039/C5TB01063B

Search articles by author

Spotlight

Advertisements