A SiO2 NP–DNA/silver nanocluster sandwich structure-enhanced fluorescence polarization biosensor for amplified detection of hepatitis B virus DNA

Jia Chen; Qiao Chen; Cunji Gao; Mingliang Zhang; Bo Qin; Hongdeng Qiu

doi:10.1039/C4TB01875C

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A SiO₂ NP–DNA/silver nanocluster sandwich structure-enhanced fluorescence polarization biosensor for amplified detection of hepatitis B virus DNA†

Jia Chen,^a Qiao Chen,^ab Cunji Gao,^a Mingliang Zhang,^a Bo Qin^a and Hongdeng Qiu*^a

Author affiliations

* Corresponding authors

^a Key Laboratory of Chemistry of Northwestern Plant Resources, Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, China
E-mail: hdqiu@licp.cas.cn
Fax: +86 931 8277088
Tel: +86 931 4968877

^b School of Materials Science and Engineering, Key Laboratory for Advanced Technologies of Materials of the Ministry of Education, Southwest Jiaotong University, Chengdu 610031, China

Abstract

A novel homogeneous biosensor based on the fluorescence polarization enhancement effect of the SiO₂ NP–DNA/Ag nanocluster sandwich structure has been developed for sensitive and selective detection of hepatitis B virus DNA.

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Article information

DOI: https://doi.org/10.1039/C4TB01875C
Article type: Communication
Submitted: 13 Nov 2014
Accepted: 09 Jan 2015
First published: 09 Jan 2015

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J. Mater. Chem. B, 2015,3, 964-967

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A SiO₂ NP–DNA/silver nanocluster sandwich structure-enhanced fluorescence polarization biosensor for amplified detection of hepatitis B virus DNA

J. Chen, Q. Chen, C. Gao, M. Zhang, B. Qin and H. Qiu, J. Mater. Chem. B, 2015, 3, 964 DOI: 10.1039/C4TB01875C

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Journal of Materials Chemistry B