Jump to main content
Jump to site search

Issue 29, 2014
Previous Article Next Article

In vitro and in vivo photothermally enhanced chemotherapy by single-walled carbon nanohorns as a drug delivery system

Author affiliations

Abstract

Single-walled carbon nanohorns (SWNHs) have exhibited many special advantages in biomedical applications. Herein, doxorubicin-loaded SWNHs (DOX-SWNHs) are prepared and further modified by amphiphilic deoxycholic acid modified-hydropropyl chitosan (DCA-HPCHS) to improve their biocompatibility. The obtained DOX-SWNH/DCA-HPCHS drug delivery system (DDS) possesses high stability in physiological media and excellent photothermal properties when exposed to laser irradiation in the near-infrared (NIR) region, which dramatically enhances the chemotherapy of DOX. Cell viability assays show that the growth of 4T1 cells are remarkably inhibitory under the conditions of incubation with DOX-SWNH/DCA-HPCHS and subsequent exposure to 808 nm laser irradiation to produce mild photothermal heating to 43 °C. Further investigation reveals that the photothermally enhanced chemotherapy derived from a promotion of DOX-SWNH/DCA-HPCHS uptake by the cancer cells rather than a light-triggered release of DOX. DOX-SWNH/DCA-HPCHS in combination with the use of laser irradiation exhibits a much better anticancer effect than the controls. Hence, the DOX-SWNH/DCA-HPCHS as a multifunctional DDS has been proposed and is hopeful for medicinal use in the future.

Graphical abstract: In vitro and in vivo photothermally enhanced chemotherapy by single-walled carbon nanohorns as a drug delivery system

Back to tab navigation

Supplementary files

Publication details

The article was received on 14 Feb 2014, accepted on 23 Apr 2014 and first published on 23 Apr 2014


Article type: Paper
DOI: 10.1039/C4TB00249K
Author version available: Download Author version (PDF)
Citation: J. Mater. Chem. B, 2014,2, 4726-4732
  •   Request permissions

    In vitro and in vivo photothermally enhanced chemotherapy by single-walled carbon nanohorns as a drug delivery system

    D. Chen, C. Wang, F. Jiang, Z. Liu, C. Shu and L. Wan, J. Mater. Chem. B, 2014, 2, 4726
    DOI: 10.1039/C4TB00249K

Search articles by author

Spotlight

Advertisements