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Issue 6, 2014
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Injectable and biodegradable supramolecular hydrogels formed by nucleobase-terminated poly(ethylene oxide)s and α-cyclodextrin

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Abstract

Injectable and biodegradable supramolecular hydrogels were prepared by nucleobase (adenine/thymine)-terminated poly(ethylene oxide)s (A-PEG-A/T-PEG-T) and α-cyclodextrin (α-CD). The supramolecular hydrogels were thoroughly characterized by WXRD, rheometer, and SEM. The gelation time depended on the molecular weight of PEG and the concentration of polymer precursors. The rheological studies showed enhanced elastic modulus (G′) of hydrogels, because of the hydrogen-bonding between A and T acting as additional network junctions. In vitro evaluation showed that the supramolecular hydrogels have acceptable biocompatibility, and are suitable for sustained and controlled release of loaded antitumor drugs. Gel formation was also confirmed when the supramolecular hydrogels were subcutaneously injected into rats. In addition, in vivo experiments employing U14 cancer cell xenograft-bearing mice showed that the intratumoral injection of a DOX-loaded A-PEG-A/T-PEG-T/α-CD gel inhibited tumor growth more effectively than that of free DOX, DOX-loaded PEG/α-CD gel, saline or gel alone. Hence, such a simple and convenient anti-cancer drug delivery system of a A-PEG-A/T-PEG-T/α-CD supramolecular hydrogel would be a promising candidate for many biomedical applications, especially in the area of the chemotherapy of solid tumors.

Graphical abstract: Injectable and biodegradable supramolecular hydrogels formed by nucleobase-terminated poly(ethylene oxide)s and α-cyclodextrin

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Publication details

The article was received on 20 Oct 2013, accepted on 08 Nov 2013 and first published on 08 Nov 2013


Article type: Paper
DOI: 10.1039/C3TB21475C
Citation: J. Mater. Chem. B, 2014,2, 659-667
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    Injectable and biodegradable supramolecular hydrogels formed by nucleobase-terminated poly(ethylene oxide)s and α-cyclodextrin

    H. Kuang, H. He, Z. Zhang, Y. Qi, Z. Xie, X. Jing and Y. Huang, J. Mater. Chem. B, 2014, 2, 659
    DOI: 10.1039/C3TB21475C

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