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Issue 17, 2014
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Biophysical characterisation, antitumor activity and MOF encapsulation of a half-sandwich ruthenium(II) mitoxantronato system

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Abstract

The novel non-conventional metallodrug [(η6-p-cymene)2Ru2mitoxantronato]Cl2 (1) exhibits redox activity, DNA intercalation ability, cathepsin B and D inhibition and in vitro antitumor activity able to circumvent cisplatin resistance. Moreover, 1 can be successfully incorporated into MIL100(Fe) as a proof of concept of the feasibility of metal–organic frameworks as carriers of non-conventional drugs.

Graphical abstract: Biophysical characterisation, antitumor activity and MOF encapsulation of a half-sandwich ruthenium(ii) mitoxantronato system

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Publication details

The article was received on 17 Oct 2013, accepted on 31 Oct 2013 and first published on 01 Nov 2013


Article type: Communication
DOI: 10.1039/C3TB21455A
Citation: J. Mater. Chem. B, 2014,2, 2473-2477
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    Biophysical characterisation, antitumor activity and MOF encapsulation of a half-sandwich ruthenium(II) mitoxantronato system

    S. Rojas, E. Quartapelle-Procopio, F. J. Carmona, M. A. Romero, J. A. R. Navarro and E. Barea, J. Mater. Chem. B, 2014, 2, 2473
    DOI: 10.1039/C3TB21455A

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