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Issue 6, 2014
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Polyurethane/β-cyclodextrin/ciprofloxacin composite films for possible medical coatings with antibacterial properties

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Abstract

Polyurethane/β-cyclodextrin/ciprofloxacin composite films have been prepared and structural and morphological behaviours reveal the progressive incorporation of the drug ciprofloxacin into polyurethane backbones. Spectral changes such as frequency shifts, band broadening and changes in the intensity are indicative of drug–polyurethane interactions. X-ray powder diffraction experiments demonstrate that ciprofloxacin retains its crystallinity in the polyurethane matrix. Electron microscopy and mercury porosimetry reveal open and interconnected macroporous pore morphology for the as-prepared polyurethane–drug films. Antimicrobial activity was evaluated by the agar disc diffusion method and the ciprofloxacin–polyurethane films demonstrate their potency as antibacterial medical systems. However, the ciprofloxacin–polyurethane films do not reveal antifungal properties.

Graphical abstract: Polyurethane/β-cyclodextrin/ciprofloxacin composite films for possible medical coatings with antibacterial properties

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Publication details

The article was received on 30 Sep 2013, accepted on 15 Nov 2013 and first published on 15 Nov 2013


Article type: Paper
DOI: 10.1039/C3TB21361G
Citation: J. Mater. Chem. B, 2014,2, 681-690
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    Polyurethane/β-cyclodextrin/ciprofloxacin composite films for possible medical coatings with antibacterial properties

    D. Macocinschi, D. Filip, S. Vlad, C. G. Tuchilus, A. F. Cristian and M. Barboiu, J. Mater. Chem. B, 2014, 2, 681
    DOI: 10.1039/C3TB21361G

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