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Issue 2, 2014
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Imaging guided photothermal therapy using iron oxide loaded poly(lactic acid) microcapsules coated with graphene oxide

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Abstract

A novel multifunctional theranostic agent has been successfully fabricated by loading iron oxide nanoparticles into poly(lactic acid) (PLA) microcapsules followed by surface functionalization with graphene oxide. Both in vitro and in vivo experiments proved that the resulting microcapsules could serve as contrast agents to simultaneously enhance ultrasound, magnetic resonance and photoacoustic imaging. The composite microcapsules show good biocompatibility and rapid response to magnetic fields. Due to the strong absorption of the near-infrared light, the composite microcapsules could efficiently kill cancer cells upon NIR laser irradiation. In addition, it was found that such a photothermal effect could be obviously enhanced by applying an external magnetic field. In a nutshell, this multifunctional microcapsule can be developed as a promising platform that integrates multimodality imaging and therapy capabilities for effective cancer theranostics.

Graphical abstract: Imaging guided photothermal therapy using iron oxide loaded poly(lactic acid) microcapsules coated with graphene oxide

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Publication details

The article was received on 17 Sep 2013, accepted on 31 Oct 2013, published on 06 Nov 2013 and first published online on 06 Nov 2013


Article type: Paper
DOI: 10.1039/C3TB21281E
Citation: J. Mater. Chem. B, 2014,2, 217-223
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    Imaging guided photothermal therapy using iron oxide loaded poly(lactic acid) microcapsules coated with graphene oxide

    X. Li, X. Liang, X. Yue, J. Wang, C. Li, Z. Deng, L. Jing, L. Lin, E. Qu, S. Wang, C. Wu, H. Wu and Z. Dai, J. Mater. Chem. B, 2014, 2, 217
    DOI: 10.1039/C3TB21281E

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