Issue 41, 2013

Incorporation of tyrosine phosphate into tetraphenylethylene affords an amphiphilic molecule for alkaline phosphatase detection, hydrogelation and calcium mineralization

Abstract

Simple conjugation of tyrosine-phosphate with tetraphenylethylene generates a new amphiphile, which not only undergoes enzymatic dephosphorylation to generate a relative hydrophobic residue for alkaline phosphatase (ALP) detection with significant enhancement of the fluorescence signals, but also self-assembles in water to result in a novel supramolecular hydrogel with gelation-enhanced fluorescence emission features upon the changes of pH. In addition, the highly ordered micelle nanostructures self-assembled from this amphiphile exhibit the ability to serve as efficient templates to promote the nucleation and growth of calcium phosphate. Since amino acids and peptides are an important class of bioactive entities whose functions range from biomolecular recognition to supramolecular self-assembly, this study demonstrates the potential to generate an amphiphile with a novel molecular architecture from the TPE and amino acid conjugate with multifunctional properties.

Graphical abstract: Incorporation of tyrosine phosphate into tetraphenylethylene affords an amphiphilic molecule for alkaline phosphatase detection, hydrogelation and calcium mineralization

Supplementary files

Article information

Article type
Paper
Submitted
24 Jul 2013
Accepted
27 Aug 2013
First published
28 Aug 2013

J. Mater. Chem. B, 2013,1, 5550-5556

Incorporation of tyrosine phosphate into tetraphenylethylene affords an amphiphilic molecule for alkaline phosphatase detection, hydrogelation and calcium mineralization

H. Liu, Z. Lv, K. Ding, X. Liu, L. Yuan, H. Chen and X. Li, J. Mater. Chem. B, 2013, 1, 5550 DOI: 10.1039/C3TB21024C

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