Issue 4, 2013
From the journal:

Journal of Materials Chemistry B

Photosensitizer-conjugated polymeric nanoparticles for redox-responsive fluorescence imaging and photodynamic therapy†

Hyunjin Kim,a   Saehun Munb  and  Yongdoo Choi*a  

* Corresponding authors

a Molecular Imaging & Therapy Branch, National Cancer Center, 323 Ilsan-ro, Goyang-si, Gyeonggi-do 410-769, Republic of Korea
E-mail: ydchoi@ncc.re.kr
Fax: +82 31-920-2529
Tel: +82 31-920-2512

b Center for Agricultural Biomaterials and Department of Biosystems and Biomaterials Science and Engineering, Seoul National University, Seoul 151-742, Republic of Korea

Abstract

Photosensitizers conjugated with hyaluronic acid via disulfide linkers were developed for biologically activatable near-infrared fluorescence imaging and photodynamic therapy. The nanoparticles prepared from the conjugate are nonfluorescent and nonphototoxic in their native state, but become highly fluorescent and phototoxic in response to reductive agents inside cancer cells.

Graphical abstract: Photosensitizer-conjugated polymeric nanoparticles for redox-responsive fluorescence imaging and photodynamic therapy

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Article information

DOI
https://doi.org/10.1039/C2TB00287F
Article type
Communication
Submitted
21 Oct 2012
Accepted
30 Nov 2012
First published
30 Nov 2012

J. Mater. Chem. B, 2013,1, 429-431

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Photosensitizer-conjugated polymeric nanoparticles for redox-responsive fluorescence imaging and photodynamic therapy

H. Kim, S. Mun and Y. Choi, J. Mater. Chem. B, 2013, 1, 429 DOI: 10.1039/C2TB00287F

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