Issue 2, 2013

Growth of gold nanowires on flexible substrate for highly sensitive biosensing: detection of thrombin as an example

Abstract

We demonstrated a facile fabrication of high density Au nanostructures including nanothorns (NTs), nanocorals (NCs), nanoslices (NSs), and nanowires (NWs) which were electrochemically grown on flexible plastic substrates of polyethylene terephthalate (PET). A thrombin-binding aptamer was immobilized on the surfaces of the Au nanostructures to form highly sensitive electrochemical impedance spectroscopic (EIS) biosensors for thrombin recognition. The binding of thrombin to the aptamer sequence was monitored by EIS in the presence of [Fe(CN)6]3−/4−(aq). The protein (1–50 pM) was detected linearly by the Au nanostructures. Among them, the Au NWs exhibited excellent thrombin detection performances. The biosensor provided high sensitivity, selectivity, and stability due to its high surface area.

Graphical abstract: Growth of gold nanowires on flexible substrate for highly sensitive biosensing: detection of thrombin as an example

Supplementary files

Article information

Article type
Paper
Submitted
23 Aug 2012
Accepted
01 Oct 2012
First published
02 Oct 2012

J. Mater. Chem. B, 2013,1, 186-193

Growth of gold nanowires on flexible substrate for highly sensitive biosensing: detection of thrombin as an example

Y. Chen, C. Lee and H. Chiu, J. Mater. Chem. B, 2013, 1, 186 DOI: 10.1039/C2TB00010E

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements