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Issue 16, 2017
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Front microrheology of the non-Newtonian behaviour of blood: scaling theory of erythrocyte aggregation by aging

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Abstract

We introduce a new framework to study the non-Newtonian behaviour of fluids at the microscale based on the analysis of front advancement. We apply this methodology to study the non-linear rheology of blood in microchannels. We carry out experiments in which the non-linear viscosity of blood samples is quantified at different haematocrits and ages. Under these conditions, blood exhibits a power-law dependence on the shear rate. In order to analyse our experimental data, we put forward a scaling theory which allows us to define an adhesion scaling number. This theory yields a scaling behaviour of the viscosity expressed as a function of the adhesion capillary number. By applying this scaling theory to samples of different ages, we are able to quantify how the characteristic adhesion energy varies as time progresses. This connection between microscopic and mesoscopic properties allows us to estimate quantitatively the change in the cell–cell adhesion energies as the sample ages.

Graphical abstract: Front microrheology of the non-Newtonian behaviour of blood: scaling theory of erythrocyte aggregation by aging

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Publication details

The article was received on 25 Oct 2016, accepted on 24 Mar 2017 and first published on 27 Mar 2017


Article type: Paper
DOI: 10.1039/C6SM02412B
Citation: Soft Matter, 2017,13, 3042-3047
  • Open access: Creative Commons BY license
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    Front microrheology of the non-Newtonian behaviour of blood: scaling theory of erythrocyte aggregation by aging

    C. Trejo-Soto, E. Costa-Miracle, I. Rodriguez-Villarreal, J. Cid, M. Castro, T. Alarcon and A. Hernandez-Machado, Soft Matter, 2017, 13, 3042
    DOI: 10.1039/C6SM02412B

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