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Issue 23, 2013
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The multi-faceted role of the actin cap in cellular mechanosensation and mechanotransduction

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Abstract

The perinuclear actin cap (or actin cap) is a recently characterized cytoskeletal organelle composed of thick, parallel, and highly contractile acto-myosin filaments that are specifically anchored to the apical surface of the interphase nucleus. The actin cap is present in a wide range of adherent eukaryotic cells, but is disrupted in several human diseases, including laminopathies and cancer. Through its large terminating focal adhesions and anchorage to the nuclear lamina and nuclear envelope through LINC complexes, the perinuclear actin cap plays a critical role both in mechanosensation and mechanotransduction, the ability of cells to sense changes in matrix compliance and to respond to mechanical forces, respectively.

Graphical abstract: The multi-faceted role of the actin cap in cellular mechanosensation and mechanotransduction

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Publication details

The article was received on 20 Mar 2013, accepted on 24 Apr 2013 and first published on 07 May 2013


Article type: Review Article
DOI: 10.1039/C3SM50798J
Citation: Soft Matter, 2013,9, 5516-5523
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    The multi-faceted role of the actin cap in cellular mechanosensation and mechanotransduction

    D. Kim, A. B. Chambliss and D. Wirtz, Soft Matter, 2013, 9, 5516
    DOI: 10.1039/C3SM50798J

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