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Issue 18, 2013
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Electrostatically driven interaction of silica-supported lipid bilayer nanoplatforms and a nerve growth factor-mimicking peptide

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Abstract

The interaction between lipid vesicles and NGF(1–14) peptide, mimicking nerve growth factor, was addressed to fabricate peptide-associated supported lipid bilayers (SLBs). According to a model of predominant electrostatic interactions, zwitterionic and anionic lipid vesicles were used to optimize the peptide association with the lipid membranes. Both planar silica and core–shell nanoparticles (NPs) were used as polar hydrophilic substrates to form the SLBs functionalized with the NGF peptide. The hybrid biointerface was scrutinized by a multitechnique approach with QCM-D, FRAP and fluorescence spectroscopy in terms of self-assembling kinetics, lipid lateral diffusion, and energy transfer processes in the SLB-wrapped silica NPs dye-doped in the core. The response of neuronal cells to the NGF(1–14)-SLBs highlighted their promising application as a drug delivery nanoplatform for ageing-related diseases.

Graphical abstract: Electrostatically driven interaction of silica-supported lipid bilayer nanoplatforms and a nerve growth factor-mimicking peptide

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Publication details

The article was received on 02 Mar 2013, accepted on 12 Mar 2013 and first published on 22 Mar 2013


Article type: Paper
DOI: 10.1039/C3SM50628B
Citation: Soft Matter, 2013,9, 4648-4654
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    Electrostatically driven interaction of silica-supported lipid bilayer nanoplatforms and a nerve growth factor-mimicking peptide

    A. Travaglia, C. Satriano, M. L. Giuffrida, D. La Mendola, E. Rampazzo, L. Prodi and E. Rizzarelli, Soft Matter, 2013, 9, 4648
    DOI: 10.1039/C3SM50628B

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