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Issue 20, 2011
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Calcium ions as bioinspired triggers to reversibly control the coil-to-helix transition in peptide-polymer conjugates

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Abstract

Controlling a coil-to-helix transition in peptidepolymer conjugates with soft stimuli requires the careful balancing of stabilizing and destabilizing effects in the peptide segment. The transition between two secondary structures of a bioconjugate is realized using calcium ions to establish a biomimetic control mechanism. Regulation of Ca2+-ion levels via competitive Ca2+-ion binders made the process reversible.

Graphical abstract: Calcium ions as bioinspired triggers to reversibly control the coil-to-helix transition in peptide-polymer conjugates

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Publication details

The article was received on 08 Apr 2011, accepted on 24 May 2011 and first published on 09 Jun 2011


Article type: Communication
DOI: 10.1039/C1SM05625E
Citation: Soft Matter, 2011,7, 9616-9619
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    Calcium ions as bioinspired triggers to reversibly control the coil-to-helix transition in peptide-polymer conjugates

    R. I. Kühnle, D. Gebauer and H. G. Börner, Soft Matter, 2011, 7, 9616
    DOI: 10.1039/C1SM05625E

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