Issue 13, 2011
From the journal:

Soft Matter

Synthesis of composite microgel capsules by ultrasonic spray combined with in situ crosslinking†

Lingling Zhao,a   Lijun Zhu,a   Qian Wang,a   Jiaoli Li,a   Chengliang Zhang,a   Jiguang Liu,a   Xiaozhong Qu,*a   Guanglong He,b   Yunfeng Luc  and  Zhenzhong Yang*a  

* Corresponding authors

a State Key Laboratory of Polymer Physics and Chemistry, Institute of Chemistry, Chinese Academy of Sciences, Beijing, China
E-mail: quxz@iccas.ac.cn, yangzz@iccas.ac.cn
Fax: +86-10-62559373
Tel: +86-10-82619206

b Davis Heart & Lung Research Institute, The Ohio State University, Columbus, OH, USA

c Department of Chemical and Biomolecular Engineering, University of California at Los Angeles, Los Angeles, CA, USA

Abstract

Composite microgel capsules were fabricated through an ultrasonic spray accompanied by in situ surface crosslinking between glycol chitosan (GC) and benzaldehyde capped poly(ethylene glycol) (OHC–PEG–CHO) in the nebulized droplets. The methodology enables a selective one-pot encapsulation for different functional species inside the interior cavity or within the shell. Herein lithium phthalocyanine (LiPc) microcrystals and citrate stabilized iron oxide (Fe3O4) nanoparticles were selected as model materials for the functionalization, which led to the electron paramagnetic resonance (EPR) and superparamagnetic dual performance of the composite microgel capsules. This shows the potential of the microgel capsules in diagnosis and targeting delivery applications.

Graphical abstract: Synthesis of composite microgel capsules by ultrasonic spray combined with in situ crosslinking

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Supplementary files

Article information

DOI
https://doi.org/10.1039/C1SM05305A
Article type
Paper
Submitted
21 Feb 2011
Accepted
04 May 2011
First published
27 May 2011

Soft Matter, 2011,7, 6144-6150

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Synthesis of composite microgel capsules by ultrasonic spray combined with in situ crosslinking

L. Zhao, L. Zhu, Q. Wang, J. Li, C. Zhang, J. Liu, X. Qu, G. He, Y. Lu and Z. Yang, Soft Matter, 2011, 7, 6144 DOI: 10.1039/C1SM05305A

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