Issue 11, 2010
From the journal:

Soft Matter

Lipid multilayered particles: the role of chitosan on structure and morphology†

Yuri Gerelli,*a   Maria Teresa Di Bari,a   Antonio Deriu,a   Daniel Clemensb  and  László Almásycd  

* Corresponding authors

a Dipartimento di Fisica, Università degli Studi di Parma, CNISM, INFM-CNR, Parma, Italy
E-mail: Yuri.Gerelli@fis.unipr.it

b Helmholtz-Zentrum Berlin für Materialien und Energie, Berlin, Germany

c Laboratory for Neutron Scattering, PSI and ETH Zürich, Villigen, Switzerland

d Adolphe Merkle Institute, University of Fribourg, Fribourg, Switzerland

Abstract

Multilayered nanovectors made up from a controlled binary lipid mixture (POPC and DMPS) and trimethyl chitosan (TMC) have been prepared and characterized by light- and small angle neutron scattering. The morphology and the multilayer structure of the particle outer shell has been described in detail. By varying the amount of TMC in the starting solution it is possible to tune the overall surface particle charge as well as its multilamellarity. In this way the drug loading/release properties of the particles can be controlled. Therefore the use of controlled POPC/DMPS mixtures can be a valid alternative to commercial lecithin to obtain nanovectors with specific release properties.

Graphical abstract: Lipid multilayered particles: the role of chitosan on structure and morphology

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Article information

DOI
https://doi.org/10.1039/B924616A
Article type
Paper
Submitted
24 Nov 2009
Accepted
11 Mar 2010
First published
29 Apr 2010

Soft Matter, 2010,6, 2533-2538

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Lipid multilayered particles: the role of chitosan on structure and morphology

Y. Gerelli, M. T. Di Bari, A. Deriu, D. Clemens and L. Almásy, Soft Matter, 2010, 6, 2533 DOI: 10.1039/B924616A

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