Jump to main content
Jump to site search

Issue 20, 2009
Previous Article Next Article

Pluronic polymersomes stabilized by core cross-linked polymer micelles

Author affiliations

Abstract

Vesicles from Pluronic L121 (PEO5-PPO68-PEO5) triblock copolymers were stabilized against aggregation by Pluronic P85 (PEO26-PPO40-PEO26) micelles. Both the vesicles and the micelles were reinforced by an interpenetrating polymer network from pentaerythritol tetraacrylate (PETA). AFM, electron microscopy and fluorescence labeling studies are used to investigate the morphology of the capsules. The P85 micelles are integrated into the L121 polymersome walls, while both types of Pluronic block copolymer are also non-covalently trapped in their respective interpenetrating acrylate networks. The micelle-containing vesicles retain their size upon heating until at least 33 °C. Upon cooling below room temperature the vesicles reversibly lose block copolymers. It was shown that the double-stabilized vesicles are readily internalized in HeLa and Caco-2 cells.

Graphical abstract: Pluronic polymersomes stabilized by core cross-linked polymer micelles

Back to tab navigation

Publication details

The article was received on 23 Feb 2009, accepted on 15 Jul 2009 and first published on 11 Aug 2009


Article type: Paper
DOI: 10.1039/B903656C
Citation: Soft Matter, 2009,5, 4042-4046
  •   Request permissions

    Pluronic polymersomes stabilized by core cross-linked polymer micelles

    F. Li, L. H. J. de Haan, A. T. M. Marcelis, F. A. M. Leermakers, M. A. Cohen Stuart and E. J. R. Sudhölter, Soft Matter, 2009, 5, 4042
    DOI: 10.1039/B903656C

Search articles by author

Spotlight

Advertisements