Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance upgrade on Thursday 4th of May 2017 from 8.00am to 9.00am (BST).

During this time our websites will be offline temporarily. If you have any questions please use the feedback button on this page. We apologise for any inconvenience this might cause and thank you for your patience.

Issue 12, 2008
Previous Article Next Article

Volume transition in composite poly(NIPAM)–giant unilamellar vesicles

Author affiliations


We have recently reported on the formation of composite gel vesicles prepared by the photopolymerization and crosslinking of poly(N-isopropyl-acrylamide) [poly(NIPAM)] inside phospholipid giant unilamellar vesicles (GUVs). Here we present a detailed study of the thermo-responsive behaviour of such composite vesicles. Giant vesicles filled with a poly(NIPAM) gel (gel–GUVs) exhibit a global volume phase transition, revealing a strong interaction between the gel and the phospholipid bilayer. Fluorescence studies show that the lipid membrane is not destroyed during the volume transition. The behaviour of giant vesicles filled with a poly(NIPAM) solution (sol–GUVs) depends on the volume fraction ΦNIPAM of encapsulated NIPAM, the precursor monomer for poly(NIPAM). For ΦNIPAM ≤ 0.06, we observe a frustrated demixing of the poly(NIPAM) chains in the internal medium; for ΦNIPAM ≥ 0.07, sol–GUVs behave like homogeneous spheres and undergo a global volume phase transition similar to the one observed in gel–GUVs. For high volume fractions (ΦNIPAM = 0.09) achieved by osmotic deflation of low volume fraction (ΦNIPAM = 0.03) sol–GUVs, we observe a full demixing of the internal medium into two well-separated phases.

Graphical abstract: Volume transition in composite poly(NIPAM)–giant unilamellar vesicles

Back to tab navigation
Please wait while Download options loads

Publication details

The article was received on 20 May 2008, accepted on 31 Jul 2008 and first published on 17 Sep 2008

Article type: Paper
DOI: 10.1039/B808472F
Citation: Soft Matter, 2008,4, 2486-2491
  •   Request permissions

    Volume transition in composite poly(NIPAM)–giant unilamellar vesicles

    C. C. Campillo, A. P. Schröder, C. M. Marques and B. Pépin-Donat, Soft Matter, 2008, 4, 2486
    DOI: 10.1039/B808472F

Search articles by author