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Issue 7, 2016
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Copper-catalyzed cascade annulation of unsaturated α-bromocarbonyls with enynals: a facile access to ketones from aldehydes

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Abstract

A Cu-catalyzed cascade annulation of enynals with alkenyl or alkynyl α-bromocarbonyls for the synthesis of various cyclohexenone-fused polycyclic compounds is described. Up to six new C–C bonds and four new carbocycles can be established in a single reaction, highlighting the high efficiency and step-economics of this protocol. This reaction offers a novel and straightforward entry to the synthesis of ketones featuring the addition of carbon radicals to aldehydes.

Graphical abstract: Copper-catalyzed cascade annulation of unsaturated α-bromocarbonyls with enynals: a facile access to ketones from aldehydes

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Publication details

The article was received on 28 Dec 2015, accepted on 03 Mar 2016 and first published on 04 Mar 2016


Article type: Edge Article
DOI: 10.1039/C5SC04980F
Citation: Chem. Sci., 2016,7, 4134-4139
  • Open access: Creative Commons BY license
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    Copper-catalyzed cascade annulation of unsaturated α-bromocarbonyls with enynals: a facile access to ketones from aldehydes

    C. Che, Q. Huang, H. Zheng and G. Zhu, Chem. Sci., 2016, 7, 4134
    DOI: 10.1039/C5SC04980F

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