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Issue 1, 2016
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Self-assembling α,γ-cyclic peptides that generate cavities with tunable properties

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Abstract

The design and synthesis of β-sheet-based self-assembling cyclic peptides with tunable cavities is described. The incorporation of a γ-amino acid with a hydroxyl group at C2 allows the incorporation of different groups that modify the internal properties of the resulting dimeric ensemble. These dimers can entrap different guests depending on the properties of the group at C2. The guest defines the geometry of the resulting aggregate.

Graphical abstract: Self-assembling α,γ-cyclic peptides that generate cavities with tunable properties

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Publication details

The article was received on 26 Aug 2015, accepted on 11 Sep 2015 and first published on 14 Sep 2015


Article type: Edge Article
DOI: 10.1039/C5SC03187G
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Citation: Chem. Sci., 2016,7, 183-187
  • Open access: Creative Commons BY license
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    Self-assembling α,γ-cyclic peptides that generate cavities with tunable properties

    N. Rodríguez-Vázquez, R. García-Fandiño, M. Amorín and J. R. Granja, Chem. Sci., 2016, 7, 183
    DOI: 10.1039/C5SC03187G

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