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Issue 10, 2013
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Rh(III)-catalyzed C–H activation/[4 + 3] cycloaddition of benzamides and vinylcarbenoids: facile synthesis of azepinones

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Abstract

Vinylcarbenoids are used as three-carbon components in Rh(III)-catalyzed C–H activation/[4 + 3] cycloaddition with benzamides to access azepinones. This transformation makes a feature of simple starting materials, mild reaction conditions and high efficiency. A kinetic isotope effect study was conducted and a plausible mechanism is proposed.

Graphical abstract: Rh(iii)-catalyzed C–H activation/[4 + 3] cycloaddition of benzamides and vinylcarbenoids: facile synthesis of azepinones

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Publication details

The article was received on 26 Jun 2013, accepted on 23 Jul 2013 and first published on 24 Jul 2013


Article type: Edge Article
DOI: 10.1039/C3SC51777B
Citation: Chem. Sci., 2013,4, 3912-3916
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    Rh(III)-catalyzed C–H activation/[4 + 3] cycloaddition of benzamides and vinylcarbenoids: facile synthesis of azepinones

    S. Cui, Y. Zhang, D. Wang and Q. Wu, Chem. Sci., 2013, 4, 3912
    DOI: 10.1039/C3SC51777B

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