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Issue 11, 2013
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Therapeutic nanoworms: towards novel synthetic dendritic cells for immunotherapy

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Abstract

A new class of antibody-functionalized, semi-flexible and filamentous polymers (diameter 5–10 nm, length ∼200 nm) with a controlled persistence length, a high degree of stereoregularity and the potential for multiple simultaneous receptor interactions has been developed. We have decorated these highly controlled, semi-stiff polymers with T cell activating anti-CD3 antibodies and analyzed their application potential as simple synthetic mimics of dendritic cells (sDCs). Our sDCs do not only activate T cells at significantly lower concentrations than free antibodies or rigid sphere-like counterparts (PLGA particles) but also induce a more robust T cell response. Our novel design further yields sDCs that are biocompatible and non-toxic. The observed increased efficacy highlights the importance of architectural flexibility and multivalency for modulating T cell response and cellular function in general.

Graphical abstract: Therapeutic nanoworms: towards novel synthetic dendritic cells for immunotherapy

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Publication details

The article was received on 20 May 2013, accepted on 30 Jul 2013 and first published on 02 Aug 2013


Article type: Edge Article
DOI: 10.1039/C3SC51399H
Citation: Chem. Sci., 2013,4, 4168-4174
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    Therapeutic nanoworms: towards novel synthetic dendritic cells for immunotherapy

    S. Mandal, Z. H. Eksteen-Akeroyd, M. J. Jacobs, R. Hammink, M. Koepf, A. J. A. Lambeck, J. C. M. van Hest, C. J. Wilson, K. Blank, C. G. Figdor and A. E. Rowan, Chem. Sci., 2013, 4, 4168
    DOI: 10.1039/C3SC51399H

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