Issue 8, 2013
From the journal:

Chemical Science

Ru-catalyzed intermolecular dearomatization reaction of indoles with allylic alcohols†

Xiao Zhang,a   Ze-Peng Yang,a   Chuan Liua  and  Shu-Li You*a  

* Corresponding authors

a State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032, China
E-mail: slyou@sioc.ac.cn
Fax: +86 21-5492-5087

Abstract

The intermolecular dearomatization reaction of indoles with allylic alcohols has been realized by a Ru-complex in the presence of catalytic amount of TsOH·H2O. The reaction proceeded mainly via a cascade sequence including allylic dearomatization/cyclization/allylic amination reaction, enabling the introduction of an allylic substituent at both the C-3 and N-1 positions of indoles.

Graphical abstract: Ru-catalyzed intermolecular dearomatization reaction of indoles with allylic alcohols

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Article information

DOI
https://doi.org/10.1039/C3SC51313K
Article type
Edge Article
Submitted
11 May 2013
Accepted
23 May 2013
First published
24 May 2013

Chem. Sci., 2013,4, 3239-3243

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Ru-catalyzed intermolecular dearomatization reaction of indoles with allylic alcohols

X. Zhang, Z. Yang, C. Liu and S. You, Chem. Sci., 2013, 4, 3239 DOI: 10.1039/C3SC51313K

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