Issue 9, 2013

1,2,3-Triazoles as versatile directing group for selective sp2 and sp3 C–H activation: cyclizationvs substitution

Abstract

Selective cyclization and substitution was achieved with designated 1,2,3-triazole acid auxiliary groups under Pd catalyzed C–H activation conditions. Both sp2 and sp3 C–H bonds were effectively activated, giving the desired products in good yields. This result revealed the first successful example of exclusive substitution using 1,2,3-triazole ligands, while another triazole-containing directing group dominantly gave cyclization under identical conditions.

Graphical abstract: 1,2,3-Triazoles as versatile directing group for selective sp2 and sp3 C–H activation: cyclization vs substitution

Supplementary files

Article information

Article type
Edge Article
Submitted
03 May 2013
Accepted
02 Jul 2013
First published
02 Jul 2013

Chem. Sci., 2013,4, 3712-3716

1,2,3-Triazoles as versatile directing group for selective sp2 and sp3 C–H activation: cyclization vs substitution

X. Ye, Z. He, T. Ahmed, K. Weise, N. G. Akhmedov, J. L. Petersen and X. Shi, Chem. Sci., 2013, 4, 3712 DOI: 10.1039/C3SC51211H

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements