Issue 5, 2012
From the journal:

Chemical Science

Osmium(vi) nitrido complexes bearing azole heterocycles: a new class of antitumor agents†

Wen-Xiu Ni,a   Wai-Lun Man,a   Shek-Man Yiu,a   Man Ho,a   Myra Ting-Wai Cheung,a   Chi-Chiu Ko,a   Chi-Ming Che,b   Yun-Wah Lam*a  and  Tai-Chu Lau*a  

* Corresponding authors

a Institute of Molecular Functional Materials and Department of Biology and Chemistry, City University of Hong Kong, Tat Chee Avenue, Kowloon Tong, China
E-mail: bhtclau@cityu.edu.hk, yunwlam@cityu.edu.hk

b Department of Chemistry and Open Laboratory of Chemical Biology of the Institute of Molecular Technology for Drug Discovery and Synthesis, The University of Hong Kong, Pokfulam Road, Hong Kong, China

Abstract

Eight new nitridoosmium(VI) complexes with the general formula [OsVI(N)Cl3(Hazole)2] have been synthesized and characterized. The cellular uptake and the antiproliferative activities of these compounds against a panel of human cancer cell lines have been investigated. Complexes with pyrazole derivatives (1, 2, 3 and 4) are found to possess significant in vitro cytotoxicity. Further studies of compounds 1 and 3 indicate that they induce S phase arrest in HeLa cells followed by apoptosis, possibly as a result of binding with DNA.

Graphical abstract: Osmium(vi) nitrido complexes bearing azole heterocycles: a new class of antitumor agents

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Article information

DOI
https://doi.org/10.1039/C2SC01031C
Article type
Edge Article
Submitted
08 Dec 2011
Accepted
02 Feb 2012
First published
03 Feb 2012

Chem. Sci., 2012,3, 1582-1588

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Osmium(VI) nitrido complexes bearing azole heterocycles: a new class of antitumor agents

W. Ni, W. Man, S. Yiu, M. Ho, M. T. Cheung, C. Ko, C. Che, Y. Lam and T. Lau, Chem. Sci., 2012, 3, 1582 DOI: 10.1039/C2SC01031C

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