Issue 11, 2018, Issue in Progress
From the journal:

RSC Advances

A feasible strategy for self-assembly of gold nanoparticles via dithiol-PEG for photothermal therapy of cancers†

Yingjie Fu,ab   Qishuai Feng,c   Yajing Shen,c   Mengwei Chen,c   Chang Xu,c   Yu Cheng ORCID logo *c  and  Xiang Zhou ORCID logo *ab  

* Corresponding authors

a The Institute for Advanced Studies, Wuhan University, Wuhan 430072, China
E-mail: xzhou@whu.edu.cn

b College of Chemistry and Molecular Science, Wuhan University, Wuhan 430072, China

c Shanghai East Hospital, The Institute for Biomedical Engineering and Nano Science, Tongji University School of Medicine, Shanghai 200029, China
E-mail: yucheng@tongji.edu.cn

Abstract

We designed and explored self-assembled gold nanoparticles (SAGNPs) by introducing dithiol modified polyethylene glycol (PEG) for internanoparticle cross-linking. SAGNPs could enhance uptake into cancer cells and be disintegrated by glutathione (GSH) to achieve tumor microenvironment-activated biodegradation. This assembled structure improved the photothermal effect compared to single gold nanospheres.

Graphical abstract: A feasible strategy for self-assembly of gold nanoparticles via dithiol-PEG for photothermal therapy of cancers

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Article information

DOI
https://doi.org/10.1039/C7RA12735A
Article type
Paper
Submitted
24 Nov 2017
Accepted
31 Jan 2018
First published
07 Feb 2018
This article is Open Access
Creative Commons BY license

RSC Adv., 2018,8, 6120-6124

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A feasible strategy for self-assembly of gold nanoparticles via dithiol-PEG for photothermal therapy of cancers

Y. Fu, Q. Feng, Y. Shen, M. Chen, C. Xu, Y. Cheng and X. Zhou, RSC Adv., 2018, 8, 6120 DOI: 10.1039/C7RA12735A

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