Issue 46, 2017

A single fluorescent chemosensor for multiple targets of Cu2+, Fe2+/3+ and Al3+ in living cells and a near-perfect aqueous solution

Abstract

A sulfonate-based chemosensor 1 was designed and synthesized for sensing various analytes: Cu2+, Fe2+/3+ and Al3+. Sensor 1 showed a high selectivity and sensitivity for the analytes in a near-perfect aqueous medium. Cu2+ and Fe2+/3+ could be monitored by fluorescence quenching of 1. It had sufficiently low detection limits (1.25 μM for Cu2+ and 3.96 μM for Fe3+), which were below the recommended levels of the World Health Organization for Cu2+ (31.5 μM) and the Environmental Protection Agency for Fe3+ (5.37 μM). 1 showed the high preferential selectivity for Cu2+ and Fe3+ in the presence of competitive metal ions without any interference. Importantly, pyrophosphate could be used to distinguish Fe3+ from Cu2+. In addition, this sensor could monitor Al3+ through fluorescence emission change. Moreover, 1 was successfully applied to quantify and image Al3+ in water samples and living cells. Based on photophysical studies and theoretical calculations, the sensing mechanisms of 1 for Cu2+ and Al3+ were explained, respectively.

Graphical abstract: A single fluorescent chemosensor for multiple targets of Cu2+, Fe2+/3+ and Al3+ in living cells and a near-perfect aqueous solution

Associated articles

Supplementary files

Article information

Article type
Paper
Submitted
17 May 2017
Accepted
24 May 2017
First published
31 May 2017
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2017,7, 28723-28732

A single fluorescent chemosensor for multiple targets of Cu2+, Fe2+/3+ and Al3+ in living cells and a near-perfect aqueous solution

T. G. Jo, J. M. Jung, J. Han, M. H. Lim and C. Kim, RSC Adv., 2017, 7, 28723 DOI: 10.1039/C7RA05565J

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