Wentinoids A–F, six new isopimarane diterpenoids from Aspergillus wentii SD-310, a deep-sea sediment derived fungus

Abstract

Six new isopimarane-type diterpenoid derivatives, wentinoids A–F (1–6), along with a known congener (7), were identified from a culture of Aspergillus wentii SD-310, a fungus isolated from a deep-sea sediment sample. The structures of these compounds were determined by analysis of spectroscopic data, and their absolute configurations were established by single crystal X-ray analysis or TDDFT-ECD calculations. This is the first time to report the isolation of isopimarane analogues from the fungal species Aspergillus wentii. Among these compounds, wentinoid A (1) possesses a unique 20-acetal and a 7,20-oxa-bridged functionality, while wentinoid B (2) contains an unusual 8,20-lactone-bridged scaffold. Compound 1 exhibited potent inhibitory activities against four plant-pathogenic fungi.