Chiral carbon–sulfur center formation via Pd-catalyzed asymmetric allylic thioetherification: synthesis of allylic thioethers

Abstract

Pd-catalyzed asymmetric allylic thioetherification reaction of various sodium thiolates was realized, which gave the allylic thioethers in good to high yields with high enantioselectivities. The reaction results considerably depend on the substrates and the bulky sulfur nucleophile led to excellent enantioselectivity as well.