Issue 15, 2017, Issue in Progress

Cryo scanning probe nanotomography study of the structure of alginate microcarriers

Abstract

Tissue-specific alginate microspheres surface modified with microparticles of decellularized liver tissue were prepared. The nanostructures of these microspheres were analysed by cryo scanning probe nanotomography. Modification of the surfaces of the alginate microspheres with microparticles of decellularized liver tissue increased surface roughness, the specific effective area, and the average autocorrelation length. Up to seven times more human hepatocellular carcinoma (HepG2) cells were adhered to the modified alginate microspheres than to the unmodified microspheres. The developed alginate microspheres can be used in regenerative medicine and tissue engineering as a biodegradable cell microcarriers.

Graphical abstract: Cryo scanning probe nanotomography study of the structure of alginate microcarriers

Supplementary files

Article information

Article type
Paper
Submitted
08 Nov 2016
Accepted
19 Jan 2017
First published
27 Jan 2017
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2017,7, 8808-8815

Cryo scanning probe nanotomography study of the structure of alginate microcarriers

A. E. Efimov, O. I. Agapova, L. A. Safonova, M. M. Bobrova, A. D. Volkov, L. Khamkhash and I. I. Agapov, RSC Adv., 2017, 7, 8808 DOI: 10.1039/C6RA26516B

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