Synthesis of N-aryl 2-quinolinones via intramolecular C(sp2)–H amidation of Knoevenagel products

Laichun Luo; Kaiqi Tao; Xiaozhi Peng; Chunling Hu; Yuanfeng Lu; Hong Wang

doi:10.1039/C6RA21286G

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Synthesis of N-aryl 2-quinolinones via intramolecular C(sp²)–H amidation of Knoevenagel products†

Laichun Luo,

*^a Kaiqi Tao,^a Xiaozhi Peng,^a Chunling Hu,^a Yuanfeng Lu^a and Hong Wang^a

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* Corresponding authors

^a College of Pharmacy, Hubei University of Chinese Medicine, Wuhan 430065, China
E-mail: laichunluo@163.com

Abstract

A practical synthesis of N-aryl 2-quinolinones via K₂S₂O₈-mediated intramolecular C(sp²)–H amidation of Knoevenagel products was developed. The reaction proceeded smoothly in a biphasic solvent system composed of n-butyl acetate and H₂O.

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Article information

DOI: https://doi.org/10.1039/C6RA21286G
Article type: Communication
Submitted: 24 Aug 2016
Accepted: 25 Oct 2016
First published: 26 Oct 2016

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RSC Adv., 2016,6, 104463-104466

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Synthesis of N-aryl 2-quinolinones via intramolecular C(sp²)–H amidation of Knoevenagel products

L. Luo, K. Tao, X. Peng, C. Hu, Y. Lu and H. Wang, RSC Adv., 2016, 6, 104463 DOI: 10.1039/C6RA21286G

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