Sampbenzophenones A–G, prenylated benzoylphloroglucinol derivatives from Hypericum sampsonii

Hucheng Zhu; Chunmei Chen; Dongdong Tan; Dongyan Li; Yi Guo; Guangzheng Wei; Jinwen Zhang; Jianping Wang; Zengwei Luo; Yongbo Xue; Yonghui Zhang

doi:10.1039/C6RA17885E

Sampbenzophenones A–G, prenylated benzoylphloroglucinol derivatives from Hypericum sampsonii†

Hucheng Zhu,‡^a Chunmei Chen,‡^a Dongdong Tan,^a Dongyan Li,^b Yi Guo,^a Guangzheng Wei,^a Jinwen Zhang,^b Jianping Wang,^a Zengwei Luo,^a Yongbo Xue*^a and Yonghui Zhang*^a

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* Corresponding authors

^a Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
E-mail: zhangyh@mails.tjmu.edu.cn, yongboxue@mail.hust.edu.cn

^b Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China

Abstract

Seven prenylated benzoylphloroglucinol derivatives, named sampbenzophenones A–G (1–7), together with two known analogues (8 and 9), were isolated from the aerial parts of Hypericum sampsonii. Their structures were elucidated by a combination of spectroscopic analyses including HRESIMS and NMR. Compound 6 was found to be the first natural product possessing an unusual 6,6-dimethoxy-3-methylhex-2-en-1-oxyl group. These new compounds were evaluated for their cytotoxic activities against five human cancer cell lines, of which, compound 1 exhibited moderate activities with IC₅₀ values ranging from 13.32–29.65 μM.

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Sampbenzophenones A–G, prenylated benzoylphloroglucinol derivatives from Hypericum sampsonii†

Abstract

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Sampbenzophenones A–G, prenylated benzoylphloroglucinol derivatives from Hypericum sampsonii

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