A novel NBD-based pH “on–off” fluorescent probe equipped with the N-phenylpiperazine group for lysosome imaging

Abstract

A novel PET-based fluorescent probe (LN6) targeting to lysosome was found from the synthesized NBD derivatives. This probe was equipped with the novel lysosome-targeted N-phenylpiperazine group, and could be employed to image lysosome and detect its pH change without any washing steps.