Issue 72, 2016, Issue in Progress

Brönsted acid-mediated annulations of 1-cyanocyclopropane-1-carboxylates with arylhydrazines: efficient strategy for the synthesis of 1,3,5-trisubstituted pyrazoles

Abstract

1-Cyanocyclopropane-1-carboxylates are reacted with arylhydrazines to afford 1,3,5-trisubstituted pyrazoles under the influence of a Brönsted acid. Formally, this transformation can be regarded as an annulation of three-membered rings with α-carbonyl and hydrazines. This newly efficient method provides access to a variety of structurally diverse pyrazole derivatives. The structures of five typical products were confirmed by X-ray crystallography.

Graphical abstract: Brönsted acid-mediated annulations of 1-cyanocyclopropane-1-carboxylates with arylhydrazines: efficient strategy for the synthesis of 1,3,5-trisubstituted pyrazoles

Supplementary files

Article information

Article type
Communication
Submitted
05 Jun 2016
Accepted
12 Jul 2016
First published
12 Jul 2016

RSC Adv., 2016,6, 67724-67728

Brönsted acid-mediated annulations of 1-cyanocyclopropane-1-carboxylates with arylhydrazines: efficient strategy for the synthesis of 1,3,5-trisubstituted pyrazoles

S. Xue, J. Liu, X. Qing and C. Wang, RSC Adv., 2016, 6, 67724 DOI: 10.1039/C6RA14557D

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