Issue 71, 2016, Issue in Progress

Reversible modulation of the activity of thiourea catalysts with anions: a simple approach to switchable asymmetric catalysis

Abstract

Leveraging the anion binding properties of thioureas, we show that the activity of known well-performing chiral catalysts can be reduced by coordinating anions (e.g. chloride) and restored by anion metatheses. Three benchmark enantioselective transformations were successfully studied, demonstrating the reversibility of the activation/deactivation processes.

Graphical abstract: Reversible modulation of the activity of thiourea catalysts with anions: a simple approach to switchable asymmetric catalysis

Supplementary files

Article information

Article type
Communication
Submitted
16 May 2016
Accepted
04 Jul 2016
First published
05 Jul 2016

RSC Adv., 2016,6, 66490-66494

Reversible modulation of the activity of thiourea catalysts with anions: a simple approach to switchable asymmetric catalysis

G. Foli, C. S. D'Elia, M. Fochi and L. Bernardi, RSC Adv., 2016, 6, 66490 DOI: 10.1039/C6RA12732K

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