Magnetic conducting polymer/mesoporous SiO2 yolk/shell nanomaterials: multifunctional nanocarriers for controlled release of doxorubicin

Abstract

Fe₃O₄/polyaniline@mesoporous SiO₂ yolk@shell nanostructures have been synthesized as multifunctional drug nanocarriers: the nanocavity in the yolk@shell nanostructures ensures high encapsulation of drugs, the presence of conducting polymer and mesoporous SiO₂ shell guarantee controlled release of drugs, and the Fe₃O₄ core ensures targeted location through a magnetic response. Doxorubicin was incorporated into Fe₃O₄/polyaniline@mesoporous SiO₂ yolk@shell nanocarriers with remarkably high entrapment efficiency, and the delivery system has an obvious sustained release effect.