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Issue 120, 2015
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Changes in the SNAr reaction mechanism brought about by preferential solvation

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Abstract

We herein report an experimental and theoretical study on preferential solvation effects for the reactions of 1-fluoro and 1-chloro-2,4-dinitrobenzene towards morpholine in acetonitrile, water and mixtures of them of varying compositions. A detailed kinetic study opens the possibility of analyzing preferential solvation and reaction rates. The kinetic study was complemented with an exploration of the potential energy surface in order to analyze the nature of the molecular interactions. For the fluorine derivative, this analysis reveals that the solvation of the TS in the mode TS1F-water/MeCN clearly outweighs the solvation of TS1F-MeCN/water, thereby suggesting that there is preferential solvation in favor of the aqueous phase.

Graphical abstract: Changes in the SNAr reaction mechanism brought about by preferential solvation

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Publication details

The article was received on 07 Oct 2015, accepted on 08 Nov 2015 and first published on 11 Nov 2015


Article type: Paper
DOI: 10.1039/C5RA20779G
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Citation: RSC Adv., 2015,5, 99322-99328
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    Changes in the SNAr reaction mechanism brought about by preferential solvation

    J. Alarcón-Espósito, R. A. Tapia, R. Contreras and P. R. Campodónico, RSC Adv., 2015, 5, 99322
    DOI: 10.1039/C5RA20779G

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