Issue 123, 2015

Atomic force microscopy for dynamic observation of human erythrocytes in a microfluidic system

Abstract

This study investigated the possibility of using atomic force microscopy (AFM) as a drug delivery system as well as a means to manipulate individual cells in an open microfluidic system for the rapid evaluation of human erythrocyte pathology in situ. We also examined the stability and biocompatibility of a patterned polydimethylsiloxane (PDMS) platform for use in conjunction with AFM. Our results demonstrate the effectiveness of integrating a microfluidic actuator with AFM technology to conduct in vitro medical analysis using only a miniscule quantity of human tissue.

Graphical abstract: Atomic force microscopy for dynamic observation of human erythrocytes in a microfluidic system

Article information

Article type
Paper
Submitted
02 Sep 2015
Accepted
18 Nov 2015
First published
24 Nov 2015

RSC Adv., 2015,5, 101319-101326

Author version available

Atomic force microscopy for dynamic observation of human erythrocytes in a microfluidic system

F. Kuo, M. Ho, J. Dai and M. Fan, RSC Adv., 2015, 5, 101319 DOI: 10.1039/C5RA17864A

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