Issue 60, 2015
From the journal:

RSC Advances

Palladium-catalyzed desulfurative Sonogashira cross-coupling reaction of 3-cyano assisted thioamide-type quinolone derivatives with alkynes†

You Wu,a   Yongning Xing,a   Jie Wang,a   Qi Sun,*a   Weiqi Konga  and  Franck Suzenetb  

* Corresponding authors

a State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, PR China
E-mail: sunqi@bjmu.edu.cn
Fax: +86 10 8280 1571
Tel: +86 10 8280 1504

b Institut of Organic and Analytical Chemistry, University of Orléans UMR-CNRS 7311, rue de chartres, BP 6759, 45067 Orléans Cedex 2, France

Abstract

A Pd-catalyzed Cu-mediated desulfurative Sonogashira cross-coupling reaction of thioamide-type quinolone derivatives was proposed for the construction of Csp2–Csp bonds. Alkynylated quinoline derivatives can be easily synthesized in moderate to excellent yields. The mechanism and effect of the 3-cyano on the reaction were also discussed.

Graphical abstract: Palladium-catalyzed desulfurative Sonogashira cross-coupling reaction of 3-cyano assisted thioamide-type quinolone derivatives with alkynes

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Article information

DOI
https://doi.org/10.1039/C5RA06337J
Article type
Communication
Submitted
09 Apr 2015
Accepted
21 May 2015
First published
26 May 2015

RSC Adv., 2015,5, 48558-48562

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Palladium-catalyzed desulfurative Sonogashira cross-coupling reaction of 3-cyano assisted thioamide-type quinolone derivatives with alkynes

Y. Wu, Y. Xing, J. Wang, Q. Sun, W. Kong and F. Suzenet, RSC Adv., 2015, 5, 48558 DOI: 10.1039/C5RA06337J

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