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Issue 11, 2015
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The aqueous medium-dimethylsulfoxide conundrum in biological studies

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Abstract

A series of straight and branched chain pyrogallol[4]arenes was studied and found to be essentially nontoxic to two strains of E. coli. An apparent enhancement of potency observed for kanamycin against E. coli was found to be due to the presence of DMSO in the growth media. Quantitative studies are presented that assay the effect of DMSO concentration on the apparent potency of kanamycin against E. coli.

Graphical abstract: The aqueous medium-dimethylsulfoxide conundrum in biological studies

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Publication details

The article was received on 25 Nov 2014, accepted on 15 Dec 2014 and first published on 15 Dec 2014


Article type: Paper
DOI: 10.1039/C4RA15217D
Citation: RSC Adv., 2015,5, 8088-8093
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    The aqueous medium-dimethylsulfoxide conundrum in biological studies

    S. Negin, M. R. Gokel, M. B. Patel, S. L. Sedinkin, D. C. Osborn and G. W. Gokel, RSC Adv., 2015, 5, 8088
    DOI: 10.1039/C4RA15217D

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