Curcumin-p-sulfonatocalix[4]resorcinarene (p-SC[4]R) interaction: thermo-physico chemistry, stability and biological evaluation

Abstract

The new 1 : 1 stoichiometric complex formation of curcumin–p-SC[4]R has been investigated with the aim to enhance the solubility, bioavailability, stability and anti-oxidant activity as well as decrease in vivo acute oral toxicity of curcumin by inclusion complexation. Thermodynamic parameters ΔS and ΔH are negative, indicating that the inclusion complexation was an exothermic process, which occurred spontaneously. The inclusion complex was characterised by different analytical methods, including FT-IR, PXRD, ¹H-NMR, SEM, DSC, ESI-mass, UV-Vis spectroscopy and elemental analysis.