Issue 4, 2015

Gadolinium nicotinate clusters as potential MRI contrast agents

Abstract

Three multinuclear gadolinium(III) clusters containing the nicotinate (nic) ligand, [Gd2(nic)6(H2O)4] (1), [Gd43-OH)4(Hnic)5(H2O)12](ClO4)8·7H2O (2), and [Gd43-OH)4(nic)6(H2O)6]2(ClO4)4·4H2O (3) were synthesized and characterized. Potential applications of these Gd(III) clusters as high-field magnetic resonance imaging (MRI) contrast agents were evaluated. The longitudinal relaxivities (r1) of 1–3 in water at 7 T were determined to be 10.45 ± 0.16, 9.28 ± 0.06, and 2.04 ± 0.29 mM−1 s−1 on a per Gd ion basis, respectively. In 1% agarose solution, the r1 values increased slightly to 10.37 ± 0.31, 10.74 ± 0.11, and 4.60 ± 0.29 mM−1 s−1 for 1–3, respectively. The ability to tune the number of inner-sphere water molecules, cluster sizes, organic ligands, and Gd coordination modes in such Gd(III) clusters provide interesting opportunities to further enhance the MR relaxivities for potential MRI applications.

Graphical abstract: Gadolinium nicotinate clusters as potential MRI contrast agents

Supplementary files

Article information

Article type
Paper
Submitted
01 Aug 2014
Accepted
28 Nov 2014
First published
28 Nov 2014

RSC Adv., 2015,5, 2914-2919

Author version available

Gadolinium nicotinate clusters as potential MRI contrast agents

X. Lin, Q. Zhang, J. Chen, X. Kong, L. Long, C. Wang and W. Lin, RSC Adv., 2015, 5, 2914 DOI: 10.1039/C4RA07853E

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