Issue 86, 2014

Fabrication of a novel magnetic yolk–shell Fe3O4@mTiO2@mSiO2 nanocomposite for selective enrichment of endogenous phosphopeptides from a complex sample

Abstract

A yolk–shell nanocomposite composed of a magnetic mesoporous anatase TiO2 (Fe3O4@mTiO2) core, a medium cavity and an outermost mesoporous silica (mSiO2) shell was successfully fabricated. Due to a combination of the strong magnetic response, improved diffusion of peptides, numerous affinity sites towards phosphopeptides and the size-exclusion effect, the nanocomposite demonstrated high enrichment efficacy and selectivity towards endogenous phosphopeptides from human serum.

Graphical abstract: Fabrication of a novel magnetic yolk–shell Fe3O4@mTiO2@mSiO2 nanocomposite for selective enrichment of endogenous phosphopeptides from a complex sample

Supplementary files

Article information

Article type
Communication
Submitted
15 Aug 2014
Accepted
12 Sep 2014
First published
12 Sep 2014

RSC Adv., 2014,4, 45804-45808

Author version available

Fabrication of a novel magnetic yolk–shell Fe3O4@mTiO2@mSiO2 nanocomposite for selective enrichment of endogenous phosphopeptides from a complex sample

H. Wan, J. Li, W. Yu, Z. Liu, Q. Zhang, W. Zhang and H. Zou, RSC Adv., 2014, 4, 45804 DOI: 10.1039/C4RA08692A

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