Synthesis of oxazepin-quinoxaline bis-heterocyclic scaffolds via an efficient three component synthetic protocol

Abstract

An efficient protocol has been developed to access a series of novel highly complex bis-heterocyclic oxazepin-quinoxaline derivatives. The new bifunctional compounds were synthesized via a one-pot three component reaction between 2-(2-formylphenoxy)acetic acid, an amine and 6-hydroxybenzo[f]quinoxaline-2,3-dicarbonitrile in toluene under reflux conditions without using any catalyst in good to excellent yields.