Issue 88, 2014

Synthesis of ganglioside Hp-s1

Abstract

A simple protocol for the synthesis of a ganglioside Hp-s1 (1) starting from commercially available phytosphingosine, sialic acid, and D-glucose is described. This synthesis involved a glycosylation reaction of a phytosphingosine derived acceptor with a highly active benzyl protected glucosyl donor, a second glycosylation of a glucosyl acceptor with a sialyl donor followed by Staudinger reaction, amidation, and global deprotection as key steps.

Graphical abstract: Synthesis of ganglioside Hp-s1

Supplementary files

Article information

Article type
Paper
Submitted
07 Aug 2014
Accepted
08 Sep 2014
First published
29 Sep 2014

RSC Adv., 2014,4, 47752-47761

Author version available

Synthesis of ganglioside Hp-s1

W. Chen, R. C. Sawant, S. Yang, Y. Liao, J. Liao, S. S. Badsara and S. Luo, RSC Adv., 2014, 4, 47752 DOI: 10.1039/C4RA08272A

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